AYUSH Molecular Research & Delivery Systems
Translating classical Ayurvedic wisdom into testable molecular questions, standardized active phyto-complexes, targeted drug delivery platforms, and licensed cannabinoid therapeutics.
Connecting Classical Phytotherapy to Molecular Receptors
Our research framework addresses the fundamental challenge in herbal medicine: standardizing heterogeneous plant materials into reproducible pharmaceutical candidates with quantified receptor affinities and validated pharmacokinetic exposure.
Cannabinoid Research &
AYUSH Pharm Development
Nutrason Bioscience Pvt. Ltd., in strategic association with Sheen Biotech Pvt. Ltd., is engaged in research and early-stage product design involving cannabinoid-based ingredients, including non-intoxicating Cannabidiol (CBD), Cannabigerol (CBG), and THCA.
Interacting intimately with the human endocannabinoid system (ECS), these molecular compounds hold remarkable supportive promise for oncology-supportive wellness, restorative sleep architecture, stress regulation, neuromuscular comfort, and chronic inflammatory relief.
Combining Sheen Biotech's specialized capabilities in cannabinoid formulation design, novel delivery mechanisms, and analytical chromatography with Nutrason's deep AYUSH Pharm expertise to pioneer legally compliant, standardized cannabinoid science in India.
Raw-Material Authentication
Legally sourced, fully traceable botanical origin with strict screening for pesticides, heavy metals, residual solvents, and microbial safety.
Profiling & Standardization
Establishing rigorous specifications for CBD concentration, permitted legal THC limits, cannabinoid purity, and batch-to-batch uniformity.
Molecular & Bioavailability Synergy
Analyzing molecular receptor interactions and harmonizing cannabinoid isolates with synergistic Ayurvedic botanicals (Ashwagandha, Shallaki, Brahmi).
Dosage-Form Optimization
Formulating sublingual drops, tinctures, capsules, softgels, topical transdermal gels, ointments, and customized delivery solutions.
Quality Assurance & Stability
Accelerated climatic zone stability tests, packaging compatibility, shelf-life verification, and comprehensive pharmacovigilance.
Advanced Pharmaceutical Delivery Systems
Botanical actives often suffer from poor aqueous solubility, rapid first-pass hepatic metabolism, and low gastrointestinal permeability. Nutrason designs tailored pharmaceutical delivery systems to maximize therapeutic bioavailability and ensure clinical batch reproducibility.
Self-Nanoemulsifying Systems (SNEDDS & SEDDS)
Isotropic anhydrous mixtures of therapeutic oils, surfactants, and co-surfactants that spontaneously form fine oil-in-water nano-droplets (20–100 nm) upon contact with gastrointestinal fluids.
- Target Actives: Highly lipophilic phytocannabinoids (CBD/CBG), Curcuminoids, Boswellic acids.
- Pharmacokinetic Benefit: Bypasses intestinal P-glycoprotein efflux and increases lymphatic transport, elevating bioavailability by up to 400%.
- Dosage Form: Liquid-filled hard gelatin or HPMC vegetarian capsules.
Modified-Release & Gastro-Resistant Tablets
Polymeric hydrophilic matrix tablets and enteric film-coated solid platforms engineered to resist acidic gastric degradation (pH 1.2) and release standardized botanical actives selectively in the alkaline intestinal lumen (pH 6.8).
- Target Actives: Acid-sensitive withanolides, saponin glycosides, and therapeutic enzymes.
- Pharmacokinetic Benefit: Prevents premature gastric hydrolysis and extends therapeutic plasma concentration over an 8 to 12-hour window.
- Dosage Form: Bi-layer compressed tablets, enteric film-coated caplets.
Phytosome & Phospholipid Complexation
Patented stoichiometric molecular complexes wherein individual polyphenolic molecules are chemically bonded to dietary phospholipids (phosphatidylcholine), transforming poorly absorbed hydrophilic/lipophilic phytocomplexes into highly permeable lipid-compatible vesicles.
- Target Actives: Curcumin C3, Boswellia AKBA, Green Tea EGCG, Silymarin.
- Pharmacokinetic Benefit: Drastically accelerates passive enterocyte absorption; achieves up to 5-fold higher peak plasma concentration (Cmax).
- Dosage Form: Standardized powder suspensions, high-potency capsules.
Sublingual & Buccal Mucosal Droppers
Micronized tincture droppers and hydro-ethanolic botanical solutions formulated for sublingual capillary plexus absorption directly into systemic circulation via the jugular vein.
- Target Actives: Pure CBD/CBG isolates, Valeriana (Tagara), Jatamansi, Shankhpushpi.
- Pharmacokinetic Benefit: Completely circumvents liver first-pass metabolism; delivers rapid onset of action within 15–25 minutes for acute palliative pain and sleep latency.
- Dosage Form: Calibrated medical dropper bottles with tamper-evident pipettes.
Penetration-Enhanced Hydrogels & Emulsions
Non-greasy, biomimetic topical lipid emulsions and aqueous hydrogels engineered with natural terpenes (menthol, cineole) and cold-pressed seed oils that reversibly fluidize stratum corneum lipids.
- Target Actives: Nirgundi extract, Shallaki, Aloe barbadensis inner fillet, Yashad Bhasma.
- Pharmacokinetic Benefit: Delivers concentrated anti-nociceptive actives directly to deep articular tissues without systemic gastric exposure.
- Dosage Form: Airless pump dispensers, laminate tubes.
Micro-Encapsulated Dry Suspensions & Granules
Spray-dried polymeric encapsulation utilizing maltodextrin and modified acacia gum matrices to protect volatile phytoconstituents (essential terpenes, monoterpenes) against thermal degradation and oxidation.
- Target Actives: Aromatic digestive bitters, volatile monoterpenes, pediatric nutraceutical matrices.
- Pharmacokinetic Benefit: Masks intense bitterness and enables instantaneous, clump-free aqueous dispersion for pediatric and convalescent consumption.
- Dosage Form: Moisture-sealed sachets, dispersible oral granules.
Investigational Molecules & Cellular Pathways
Nutrason investigates characterized botanical single molecules and standardized multi-compound complexes across documented cellular signaling pathways.
Withaferin A
Withania somnifera (Ashwagandha)Steroidal lactone investigated for binding to heat-shock protein 90 (HSP90), downregulating NF-κB, and modulating cytoskeletal vimentin in breast cancer and lymphoma models.
Curcuminoids C3 Complex
Curcuma longa (Haridra)Standardized tricurcuminoid mixture (Curcumin, Demethoxycurcumin, Bisdemethoxycurcumin) inhibiting COX-2, 5-LOX, TNF-α, and downstream pro-inflammatory interleukins.
Thymoquinone
Nigella sativa (Kalonji)Bioactive quinone investigated in cell and animal models for mitochondrial apoptosis induction and potentiation of conventional chemotherapeutic sensitivity.
Berberine Hydrochloride
Berberis aristata (Daruharidra)Isoquinoline alkaloid with documented clinical trial evidence for reducing colorectal adenoma recurrence through AMP-activated protein kinase (AMPK) activation.
Acetyl-11-Keto-β-Boswellic Acid
Boswellia serrata (Shallaki)Pentacyclic triterpene that acts as a non-redox, allosteric inhibitor of 5-lipoxygenase (5-LOX), selectively blocking leukotriene B4 synthesis without gastric ulceration.
Cannabidiol & Cannabigerol (CBD/CBG)
Cannabis sativa (Licensed Sourcing)Non-intoxicating phytocannabinoids with diverse multi-target pharmacology across the endocannabinoid system, TRPV1 vanilloid receptors, and 5-HT1A serotonergic pathways.
6-Stage Analytical Quality Protocol
Every investigational formulation developed by Nutrason undergoes strict analytical screening to ensure zero heavy metal contamination, zero solvent residues, and exact phytochemical marker quantification.
DNA Barcoding & Identity
Verification of exact botanical species and taxonomic authenticity to eliminate cross-species contamination.
HPLC/HPTLC Fingerprint
High-Performance Thin-Layer and Liquid Chromatography to quantify active marker peaks against primary reference standards.
GC-MS Residual Solvents
Gas Chromatography-Mass Spectrometry confirming compliance with ICH Q3C limits for extraction solvents.
ICP-MS Heavy Metals
Inductively Coupled Plasma Mass Spectrometry quantifying Lead, Arsenic, Cadmium, and Mercury down to parts-per-billion (ppb).
Research Governance & CYP450 Interaction Screening
In accordance with ethical hospital collaboration guidelines, Nutrason screens all botanical candidates for potential interactions with Cytochrome P450 enzymes (CYP3A4, CYP2C9, CYP2D6). This protects patients undergoing chemotherapy or taking conventional cardiovascular/neurological medications from unanticipated pharmacokinetic fluctuations.
Collaborate With Our Molecular R&D Team
Connect with our pharmacologists and formulation scientists to discuss investigational delivery systems, hospital clinical protocols, or customized AYUSH proprietary medicine supply.